Tardigrade Movies and Pictures

Clark-Hachtel CM, Hibshman JD, De Buysscher T, Stair ER, Hicks LM, Goldstein B (2024). The tardigrade Hypsibius exemplaris dramatically upregulates DNA repair pathway genes in response to ionizing radiation. Current Biology 34:1819-1830.

Hibshman JD, Clark-Hachtel CM, Bloom KS, Goldstein B (2024). A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants. Cell Reports 43:114956. doi 10.1016/j.celrep.2024.114956.

Harry CJ*, Hibshman JD*, Damatac A, Davidson PL, Estermann MA, Flores-Flores M, Holmes CM, Lázaro J, Legere EA, Leyhr J, Thendral SB, Vincent BA, Goldstein B (2024). Protocol for fluorescent live-cell staining of tardigrades. STAR Protocols 5:103232.

Heikes KL, Goldstein B. Expression patterns of FGF and BMP pathway genes in the tardigrade Hypsibius exemplaris. bioRxiv 2024.01.29.577774; doi: https://doi.org/10.1101/2024.01.29.577774

Heikes KL, Game M, Smith FW, Goldstein B (2023). The Embryonic Origin of Primordial Germ Cells in the Tardigrade Hypsibius exemplaris. Developmental Biology 497:42-58.

Hibshman JD, Carra S, Goldstein B (2023). Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation. Communications Biology, 6:121 doi:10.1038/s42003-023-04512-y.

Goldstein B (2022) Tardigrades. Nature Methods 19:904-905.

Goldstein B (2022). Tardigrades and their emergence as model organisms, in B Goldstein and M Srivastava, Emerging Model Systems in Developmental Biology (pp 173-198), Academic Press.

Giovannini I, Boothby TC, Cesari M, Goldstein B, Guidetti R, Rebecchi L (2022). Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis. Scientific Reports 12:1938.

Hibshman JD, Clegg JS, Goldstein B (2020). Mechanisms of Desiccation Tolerance: Themes and Variations in Brine Shrimp, Roundworms, and Tardigrades. Frontiers in Physiology 11:592016.

Goldstein B (2018). The emergence of the tardigrade Hypsibius exemplaris as a model system. CSH Protocols 10:859-866.

McGreevy KM, Heikes KL, Kult S, Tharp ME, and B Goldstein (2018). Fluorescent cell staining nethods for living Hypsibius exemplaris embryos. CSH Protocols 10:878-884.

Heikes KL and B Goldstein (2018). Live imaging of tardigrade embryonic development by differential interference contrast microscopy. CSH Protocols 10:974-877.

Smith FW, Cumming M, Goldstein B (2018). Analyses of nervous system patterning genes in the tardigrade Hypsibius exemplaris illuminate the evolution of panarthropod brains. EvoDevo 9:19.

Smith FW, Bartels PJ, and Goldstein B (2017). A hypothesis for the composition of the tardigrade brain and its implications for panarthropod brain evolution. Integrative and Comparative Biology 57:546-559.

Boothby TC, Tapia H, Brozena AH, Piszkiewicz S, Smith AE, Giovanninni I, Rebecchi L, Pielak GJ, Koshland D, and B Goldstein (2017). Tardigrades use intrinsically disordered proteins to survive desiccation. Molecular Cell 65:975-984.

Smith FW and B Goldstein (2017). Segmentation in Tardigrada and diversification of segmental patterns in Panarthropoda. Arthropod Structure & Development 46:328-340.

Russell JJ, Theriot JA, Sood P, Marshall WF, Landweber LF, Fritz-Laylin L, Polka JK, Oliferenko S, Gerbich T, Gladfelter A, Umen J, Bezanilla M, Lancaster MA, He S, Gibson MC, Goldstein B, Tanaka EM, Hu C-K, and Brunet A (2017). Non-model model organisms. BMC Biology 15:55.

Smith FW, Boothby TC, Giovannini I, Rebecchi L, Jockusch EL, and B Goldstein (2016). The compact body plan of tardigrades evolved by the loss of a large body region. Current Biology 26:224-229. (and a Dispatch article)

Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Osborne Nishimura E, Tintori SC, Li Q, Jones CD, Yandell M, Messina DN, Glasscock J, and Goldstein B (2015). Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. PNAS 112:15976-15981 and follow-up letter

Tenlen, J.R., S. McCaskill and B. Goldstein (2013). RNA interference can be used to disrupt gene function in tardigrades. Development Genes and Evolution 223:171-181. (and a Faculty Opinions review)

Gabriel WN, McNuff R, Patel SK, Gregory TR, Jeck WR, Jones CD and Goldstein B (2007). The Tardigrade Hypsibius dujardini, a New Model for Studying the Evolution of Development. Developmental Biology 312:545-559. (and a Faculty Opinions review)

Gabriel WN and Goldstein B (2007). Segmental Expression of Pax3/7 and Engrailed Homologs in Tardigrade Development. Development Genes and Evolution 217: 421-433. (and a Faculty Opinions review)

Goldstein B and Blaxter M (2002). Tardigrades. Current Biology 12: R475.

Our development of tardigrades as a model system has been supported by
National Science Foundation grants IOS 0235658, IOS 1257320,
IOS 1557432, and IOS 2028860.

Tardigrades	Goldstein Lab UNC Chapel Hill

Our publications on tardigrades (more to come!) Clark-Hachtel CM, Hibshman JD, De Buysscher T, Stair ER, Hicks LM, Goldstein B (2024). The tardigrade Hypsibius exemplaris dramatically upregulates DNA repair pathway genes in response to ionizing radiation. Current Biology 34:1819-1830. Hibshman JD, Clark-Hachtel CM, Bloom KS, Goldstein B (2024). A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants. Cell Reports 43:114956. doi 10.1016/j.celrep.2024.114956. Harry CJ, Hibshman JD, Damatac A, Davidson PL, Estermann MA, Flores-Flores M, Holmes CM, Lázaro J, Legere EA, Leyhr J, Thendral SB, Vincent BA, Goldstein B (2024). Protocol for fluorescent live-cell staining of tardigrades. STAR Protocols 5:103232. Heikes KL, Goldstein B. Expression patterns of FGF and BMP pathway genes in the tardigrade Hypsibius exemplaris. bioRxiv 2024.01.29.577774; doi: https://doi.org/10.1101/2024.01.29.577774 Heikes KL, Game M, Smith FW, Goldstein B (2023). The Embryonic Origin of Primordial Germ Cells in the Tardigrade Hypsibius exemplaris. Developmental Biology 497:42-58. Hibshman JD, Carra S, Goldstein B (2023). Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation. Communications Biology, 6:121 doi:10.1038/s42003-023-04512-y. Goldstein B (2022) Tardigrades. Nature Methods 19:904-905. Goldstein B (2022). Tardigrades and their emergence as model organisms, in B Goldstein and M Srivastava, Emerging Model Systems in Developmental Biology (pp 173-198), Academic Press. Giovannini I, Boothby TC, Cesari M, Goldstein B, Guidetti R, Rebecchi L (2022). Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis. Scientific Reports 12:1938. Hibshman JD, Clegg JS, Goldstein B (2020). Mechanisms of Desiccation Tolerance: Themes and Variations in Brine Shrimp, Roundworms, and Tardigrades. Frontiers in Physiology 11:592016. Goldstein B (2018). The emergence of the tardigrade Hypsibius exemplaris as a model system. CSH Protocols 10:859-866. McGreevy KM, Heikes KL, Kult S, Tharp ME, and B Goldstein (2018). Fluorescent cell staining nethods for living Hypsibius exemplaris embryos. CSH Protocols 10:878-884. Heikes KL and B Goldstein (2018). Live imaging of tardigrade embryonic development by differential interference contrast microscopy. CSH Protocols 10:974-877. Smith FW, Cumming M, Goldstein B (2018). Analyses of nervous system patterning genes in the tardigrade Hypsibius exemplaris illuminate the evolution of panarthropod brains. EvoDevo 9:19. Smith FW, Bartels PJ, and Goldstein B (2017). A hypothesis for the composition of the tardigrade brain and its implications for panarthropod brain evolution. Integrative and Comparative Biology 57:546-559. Boothby TC, Tapia H, Brozena AH, Piszkiewicz S, Smith AE, Giovanninni I, Rebecchi L, Pielak GJ, Koshland D, and B Goldstein (2017). Tardigrades use intrinsically disordered proteins to survive desiccation. Molecular Cell 65:975-984. Smith FW and B Goldstein (2017). Segmentation in Tardigrada and diversification of segmental patterns in Panarthropoda. Arthropod Structure & Development 46:328-340. Russell JJ, Theriot JA, Sood P, Marshall WF, Landweber LF, Fritz-Laylin L, Polka JK, Oliferenko S, Gerbich T, Gladfelter A, Umen J, Bezanilla M, Lancaster MA, He S, Gibson MC, Goldstein B, Tanaka EM, Hu C-K, and Brunet A (2017). Non-model model organisms. BMC Biology 15:55. Smith FW, Boothby TC, Giovannini I, Rebecchi L, Jockusch EL, and B Goldstein (2016). The compact body plan of tardigrades evolved by the loss of a large body region. Current Biology 26:224-229. (and a Dispatch article) Boothby TC, Tenlen JR, Smith FW, Wang JR, Patanella KA, Osborne Nishimura E, Tintori SC, Li Q, Jones CD, Yandell M, Messina DN, Glasscock J, and Goldstein B (2015). Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. PNAS 112:15976-15981 and follow-up letter Tenlen, J.R., S. McCaskill and B. Goldstein (2013). RNA interference can be used to disrupt gene function in tardigrades. Development Genes and Evolution 223:171-181. (and a Faculty Opinions review) Gabriel WN, McNuff R, Patel SK, Gregory TR, Jeck WR, Jones CD and Goldstein B (2007). The Tardigrade Hypsibius dujardini, a New Model for Studying the Evolution of Development. Developmental Biology 312:545-559. (and a Faculty Opinions review) Gabriel WN and Goldstein B (2007). Segmental Expression of Pax3/7 and Engrailed Homologs in Tardigrade Development. Development Genes and Evolution 217: 421-433. (and a Faculty Opinions review) Goldstein B and Blaxter M (2002). Tardigrades. Current Biology 12: R475. Our development of tardigrades as a model system has been supported by National Science Foundation grants IOS 0235658, IOS 1257320, IOS 1557432, and IOS 2028860.
Movies Pictures Tree of Life Tardi-what?	Links Protocols Publications